Sandrine thuret biography

Neurogenesis and Mental Health: Environmental and molecular regulatory mechanisms.

I am head of the Neurogenesis and Mental Health Laboratory and our research focuses on environmental and molecular regulatory mechanisms controlling hippocampal neurogenesis in health and disease.

The adult mammalian brain contains small populations of neural stem cells dividing and differentiating into neurons.

Sandrine thuret biography

This process of neurogenesis occurs in the subgranular zone of the hippocampal dentate gyrus. Adult hippocampal neurogenesis (AHN) decreases with age and elderly animals display impaired learning and memory abilities, whereas increased AHN is linked to improved learning and memory.

Moreover, AHN is reduced by stressful experiences and in animal models of depression, whereas many antidepressant treatments have been shown to enhance and are dependent on functional AHN. Therefore, AHN strongly emerges as an advantageous target for counteracting the effect of ageing and stress and thus p